Famotidine 20 mg, 20 tablets. Tablet, Famotidine 40 mg, 10 tablets. DESCRIPTION ... thrombocytopenia. – Hypersensitivity: anaphylaxis, angioedema, orbital or ...Introduction. Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease in the platelet count and increased risk of bleeding [].ITP in adults is a clinically distinct condition from that in children, with a lower likelihood of spontaneous remission, a higher incidence of underlying diseases and …Dec 10, 2017 · Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis,<i> Clostridium ... Famotidine tablets are a histamine-2 (H 2) receptor antagonist indicated ( 1 ): In adult and pediatric patients 40 kg and greater for the treatment of: • active duodenal ulcer (DU). • active gastric ulcer. • symptomatic nonerosive gastroesophageal reflux disease (GERD). • erosive esophagitis due to GERD, diagnosed by biopsy.Thrombocytopenia (throm-buh-sye-tuh-PEE-nee-uh) is when there aren't as many normal platelets in the blood as there should be. Platelets are tiny colorless cells in the blood that help the blood clot. Like all blood cells, platelets are made in the bone marrow (the spongy inner part of bones). The phase IV clinical study analyzes which people take Pepcid and have Thrombocytopenia. It is created by eHealthMe based on reports of 48,403 people who have side effects when taking Pepcid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions. Phase IV trials are used to detect adverse ...Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterized by a low platelet count, purpura, and hemorrhagic episodes caused by antiplatelet autoantibodies. The diagnosis is typically made by excluding the known causes of thrombocytopenia. IgG autoantibodies sensitize the circulating platelets. It leads to the …26 ene 2022 ... Famotidine. Disclaimer: Official controlled document is the CHEO and ... Hematologic:: thrombocytopenia; Hepatic: increase in liver enzymes ...Kansas Journal of Medicine 2015 Famotidine-Induced Thrombocytopenia 29 Drug Intell Clin Pharm 1989; 23(6):507-508. PMID: 2568035 5 Zimmermann AE, Katona BG, Hrehorovich VR. Probable famotidine-induced thrombocytopenia. 1991; DICP 25(6):678. PMID: 1877281. 6 Humphries JE. Thrombocytopenia associated with famotidine in aProton pump inhibitors (PPIs) are not widely recognized as a cause of drug-induced thrombocytopenia. Literature is mainly confined to case reports and has been insufficient to explore the possibility that this adverse event may be attributed to a class effect of PPI therapy. We present a case where platelet counts dropped from 177 (×10 (3) per ... A Word From Verywell. Thrombocytopenia is the medical term for a low platelet count. Platelets are blood cells that stop bleeding by causing blood to clot. Thrombocytopenia is defined as a platelet count of less than 150,000 platelets/mL, regardless of your age. Andrew Brookes / Getty Images.4 oct 2023 ... ... thrombocytopenia. The relationship between these events and famotidine therapy has been unclear in many cases.[44392]. Miscellaneous adverse ...Hematologic: thrombocytopenia. Hypersensitivity: ... Famotidine Tablets USP, 40 mg are available as tan, round, unscored, film-coated tablets, debossed with “5729” on one side and “TEVA” on the other side, containing 40 mg famotidine, packaged in bottles of 100 (NDC 0172-5729-60) and 500 (NDC 0172-5729-70) tablets. ...The purpose of this study was to assess the incidence and clinical significance of famotidine-associated thrombocytopenia in the trauma patient population. A retrospective cohort study was performe...Thrombocytopenia is a condition that develops because your body does not have enough platelets. Platelets are cells that help your blood to clot. Your body may not be making enough platelets, or it may be destroying too many platelets. When platelets become low, your risk for bleeding increases. Severe bleeding may become life-threatening.Report signs of agranulocytosis and neutropenia (fever, sore throat, mucosal lesions, signs of infection, bruising), aplastic anemia (unusual fatigue, weakness), or thrombocytopenia (bruising, bleeding gums, nose bleeds).Probable Famotidine-Induced Thrombocytopenia Authors Ahmad Rahal University of Kansas Medical Center:KU School of Medicine-Wichita, 1010 North Kansas, Wichita, KS 67214-3199, USA.pantoprazole to famotidine due to possible PPI-induced thrombocytopenia. Consequently, pantoprazole therapy was discontinued, oral famotidine 10 mg once daily was initiated, and 2 units of platelets were 2022 Phan et al. Cureus 14(2): e22326. DOI 10.7759/cureus.22326 2 of 6In patients with severe thrombocytopenia, predicted 5-year mortality rates from bleeding are significantly raised in patients older than age 60 and those under age 40 -- 47.8% versus 2.2% ...Hematologic: thrombocytopenia . Hypersensitivity: orbital edema, rash, conjunctival injection, bronchospasm . ... Famotidine tablets may be taken with or without food. Famotidine tablets may be given with antacids. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.Generic Name Mirtazapine DrugBank Accession Number DB00370 Background. Mirtazapine is a tetracyclic piperazino-azepine antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. 13 This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of …Hematologic: thrombocytopenia. Hypersensitivity: ... Famotidine Tablets USP, 40 mg are available as tan, round, unscored, film-coated tablets, debossed with “5729” on one side and “TEVA” on the other side, containing 40 mg famotidine, packaged in bottles of 100 (NDC 0172-5729-60) and 500 (NDC 0172-5729-70) tablets. ...Reversible neutropenia and thrombocytopenia during famotidine treatment. Ann Pharmacother. 1994 Mar;28 (3):406-7. doi: 10.1177/106002809402800326.Thrombocytopenia has been reported rarely with IV and oral famotidine and may increase the risk of bleeding (Ref). Most patients who developed thrombocytopenia ...Famotidine can cause thrombocytopenia, which refers to a low blood level of platelets. Platelets are a kind of cell that helps your blood clot. In studies of the drug, ...Famotidine can be sold to the public for adults and children over 16 years (provided packs do not contain more than 2 weeks’ supply) for the short-term symptomatic relief of heartburn, dyspepsia, and hyperacidity, and for the prevention of these symptoms when associated with consumption of food or drink including when they cause sleep disturbance (max. single dose 10 mg, max. daily dose 20 mg). Heparin-Induced Thrombocytopenia (HIT) is a prothrombotic adverse drug reaction. One third to one-half of cases of HIT are complicated by thrombosis, which may be limb- or life-threatening. Recommendations address screening of asymptomatic patients for HIT, diagnosis and initial management of patients with suspected HIT, treatment of acute HIT, and special situations in …Famotidine is a white to pale yellow crystalline compound that is freely soluble in glacial acetic acid, slightly soluble in methanol, very slightly soluble in water, and practically insoluble in ethanol. Each tablet for oral administration contains either 20 mg or 40 mg of famotidine and the followingShalev, O, Seror, D. Cimetidine and ranitidine may not cross-react to cause thrombocytopenia. J Intern Med 1991 ; 230: 87 – 8 . Google Scholar | Crossref | Medline | ISIThrombocytopenia due to H2-receptor antagonist is a rare but known phenomenon. By 2011, there were 29 cases of H2-receptor antagonist-induced thrombocytopenia. These cases were a mix of ranitidine, famotidine, and cimetidine-induced thrombocytopenia [23,24]. Majority of these 29 studies wereFamotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. It is used to treat peptic ulcer disease, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. It is taken by mouth or by injection into a vein. It begins working within an hour. Common side effects include headache, intestinal upset ...One of the most common treatments for patients with a low platelet count, medically known as thrombocytopenia, is prescription glucocorticoids, immunosuppressive drugs or thrombopoietin receptor agonists.Mar 15, 2023 · Thrombocytopenia — Patients with critical or life-threatening bleeding and a low platelet count (<50,000/microL) should be transfused with platelets. Limited data suggest that proceeding with upper endoscopy in patients with thrombocytopenia is generally safe [ 28 ], though whether there is a lower limit below which endoscopy should be ... Heparin-Induced Thrombocytopenia (HIT) is a prothrombotic adverse drug reaction. One third to one-half of cases of HIT are complicated by thrombosis, which may be limb- or life-threatening. Recommendations address screening of asymptomatic patients for HIT, diagnosis and initial management of patients with suspected HIT, treatment of acute HIT, and special situations in …Thrombocytopenia is a condition that develops because your body does not have enough platelets. Platelets are cells that help your blood to clot. Your body may not be making enough platelets, or it may be destroying too many platelets. When platelets become low, your risk for bleeding increases. Severe bleeding may become life-threatening.Trivalent inactivated influenza vaccination was reported to precede the sudden occurrence of severe thrombocytopenia by 6-7 days in 2010, 2012 and 2013 in a 4 year-old boy. 6 The authors' interpretation was that the influenza vaccine induced primary immune thrombocytopenia (ITP), rather than DITP, because ITP has been previously associated with ...To address this common clinical problem, we used 3 distinct analytical methods and their corresponding datasets to identify drugs that have evidence for an association with thrombocytopenia: (1) We performed serial systematic reviews of published case reports of DITP and analyzed the clinical evidence for a causal association of the drug with thrombocytopenia. 9,10 (2) We analyzed data from ...Stress-related injury is superficial mucosal damage that presents primarily as erosions, whereas stress ulcers are deep, focal mucosal damage penetrating the submucosa with high risk for gastrointestinal bleeding ( 2, 3 ). Mucosal damage has been reported to occur during the first 24 hours of hospital admission in 75% to 100% of intensive care ... General/Misc: Acetaimonphen, Aspirin, Danazol, Famotidine, NSAIDs (esp. Diclofenac, Ibuprofen, Indomethacin, Naproxen), Pantoprazole, Quinine (found in tonic water, mixed drinks) More information including more detailed up-to-date lists here .Nov 23, 2018 · Proton pump inhibitors might induce leukopenia and thrombocytopenia. Neutrophil and platelet counts may go back to the normal range after proton pump inhibitors are stopped. Clinicians should be aware of this adverse effect even though it is very rare. Open in a separate window. In patients with severe thrombocytopenia, predicted 5-year mortality rates from bleeding are significantly raised in patients older than age 60 and those under age 40 -- 47.8% versus 2.2% ...feeling of warmth. hearing loss. inability to have or keep an erection. lack or loss of strength. loss in sexual ability, desire, drive, or performance. muscle pain or stiffness. redness of the face, neck, arms and occasionally, upper chest. redness of the white part of the eyes. stomach discomfort.Hospitalized patients may experience delirium and thrombocytopenia when receiving an H 2 RA . The frequency of ADRs may increase in renally impaired, elderly, and malnourished patients ( 5 , 7 ). Central nervous system disturbances caused by H 2 RAs and electrolyte accumulation due to antacids are seen more frequently in these patient ...The patient developed thrombocytopenia one year later when placed on nadolol and famotidine during admission for a gastrointestinal bleed. The platelet count decreased during the admission. Both drugs were discontinued after the last platelet count (100 x 10(3)/mm(3)).Our findings revealed that there was a significant reduction in thrombocytopenia in the famotidine group compared to placebo group. Moreover, the …Hematologic: thrombocytopenia. Hypersensitivity: orbital edema, rash, conjunctival injection, bronchospasm. ... Famotidine was negative in the microbial mutagen test (Ames test) using Salmonella typhimurium and Escherichia coli with or without rat liver enzyme activation at concentrations up to 10,000 mcg/plate.2023 ASCO Annual Meeting. Springer Medicine. SearchMar 1, 2008 · Patients receiving other drugs or with known bleeding in the upper part of the gastrointestinal tract, thrombocytopenia, or coagulopathy were excluded. Results A total of 522 patients who received famotidine and 95 who received pantoprazole were included. Post-hoc analysis revealed a higher incidence of > 20% drop in platelet count in the study group compared with the controls (23%; 95% CI = 19 - 27% versus 11%; 95% CI = 8 - 14%, respectively; p < 0.001). This study failed to demonstrate an increased incidence of thrombocytopenia for patients treated with pantoprazole.In patients with severe thrombocytopenia, predicted 5-year mortality rates from bleeding are significantly raised in patients older than age 60 and those under age 40 -- 47.8% versus 2.2% ...Thrombocytopenia means there are low levels of circulating platelets. A platelet count below 150,000/ µL is considered low. As such, a platelet count of 20,000/µL is consistent with a diagnosis of thrombocytopenia. A normal hemoglobin level is 12-17 g/dL depending on the sex of the patient.Famotidine can cause thrombocytopenia, which refers to a low blood level of platelets. Platelets are a kind of cell that helps your blood clot. In studies of the drug, ...Stress-related injury is superficial mucosal damage that presents primarily as erosions, whereas stress ulcers are deep, focal mucosal damage penetrating the submucosa with high risk for gastrointestinal bleeding ( 2, 3 ). Mucosal damage has been reported to occur during the first 24 hours of hospital admission in 75% to 100% of intensive care ... Thrombocytopenia is any disorder in which there are not enough platelets. Platelets are elements in the blood that help the blood clot. A low platelet count makes …Intravenous famotidine therapy was the only variable found to be statistically significant after both univariate and multivariate analysis (P < 0.001 and P = 0.003, respectively). Thrombocytopenia became clinically significant in eight of 181 (4.4%) famotidine-treated patients or 11.1 per cent of those who developed thrombocytopenia.Thrombocytopenia Associated with Famotidine in a Hemophiliac. Show details Hide details. John E. Humphries. Annals of Pharmacotherapy. Feb 1992. Restricted access. Rifampin-Induced Severe Thrombocytopenia in a Patient with Pulmonary Tuberculosis. Show details Hide details. Jose M. Kindelán and more ...In these Ranitidine · Famotidine · Platelet patients it is often difficult to assess count No financial support was provided in any accurately the cause of adverse ef- part for this paper fects such as thrombocytopenia. Abstract. H 2 antagonist ranitidine causing thrombocytopenia is a rare drug phenomenon. Here we present a case of 55 year old female of pustular psoriasis who presented with fever and vomiting. Patient. was started on roxithromycin, iv ondensetron, paracetamol and iv ranitidine. Complete blood count revealed neutrophilia with normal blood picture.Thrombocytopenia is defined as a platelet count <150,000/mcL. 1 The blood abnormality is either suspected based on the pa-tient’s signs or symptoms, such as ecchymoses, petechiae, pur- ... • Famotidine • Fluconazole • Furosemide • Gentamicin • Hydrochlorothiazide/ triamterene • Meropenem • Phenytoin • Piperacillin • QuinineSignificant: CNS effects including confusion, disorientation, hallucinations, delirium, agitation, lethargy and seizure (particularly in elderly and patients with renal impairment); may increase the risk of developing community-acquired pneumonia; may decrease the absorption of vitamin B 12. Blood and lymphatic system disorders: Rarely, …Thrombocytopenia. Famotidine can cause thrombocytopenia, which refers to a low blood level of platelets. Platelets are a kind of cell that helps your blood clot.26 ene 2022 ... Famotidine. Disclaimer: Official controlled document is the CHEO and ... Hematologic:: thrombocytopenia; Hepatic: increase in liver enzymes ...A dichotomous dose effect of acid suppressants was analyzed according to the mean daily dose while receiving mechanical ventilation, with high daily dose defined for H 2 RAs as greater than 40 mg for famotidine, greater than 150 mg for ranitidine hydrochloride if intravenous or greater than 300 mg if enteral, greater than 300 mg for nizatidine ...Drug-Induced Immune Thrombocytopenia Results of the Testing for Drug-Dependent Platelet-Reactive Antibodies by the BloodCenter of Wisconsin Data are from 1995-2018, provided with the permission of Daniel Bougie PhD, Janice McFarland MD, Brian Curtis, PhD and Richard Aster, MDIn other ways it bears a very close resemblance to cimetidine; for example, headache and confusion with intravenous use are reported, as are thrombocytopenia and pancytopenia (SEDA-15, 395). The effects of famotidine 20 mg bd and omeprazole 20 mg/day for 8 weeks have been compared in the treatment of reflux esophagitis in a randomized trial in ...Drug-induced thrombocytopenia occurs when certain medicines destroy platelets or interfere with the body's ability to make enough of them. There are two types of drug-induced thrombocytopenia: immune and nonimmune. If a medicine causes your immune system to produce antibodies which seek and destroy your platelets, the condition is called drug ...Sep 23, 2010 · To address this common clinical problem, we used 3 distinct analytical methods and their corresponding datasets to identify drugs that have evidence for an association with thrombocytopenia: (1) We performed serial systematic reviews of published case reports of DITP and analyzed the clinical evidence for a causal association of the drug with thrombocytopenia. 9,10 (2) We analyzed data from ... While hematologi- cal side effects for famotidine, including neu- tropenia and thrombocytopenia, have been reported, albeit rarely [18-21], plasmacytosis.Our hypothesis is that Famotidine (an H2RA) is as effective as Pantoprazole (a PPI) in stress ulcer prophylaxis in mechanically ventilated patients. ... Patients receiving both drugs, with known GIB, thrombocytopenia, or coagulopathy were excluded. RESULTS: 522 and 95 patients were included in the H2RA and PPI groups respectively. GIB ...Nov 19, 2021 · Famotidine tablets are a histamine-2 (H 2) receptor antagonist indicated ( 1 ): In adult and pediatric patients 40 kg and greater for the treatment of: • active duodenal ulcer (DU). • active gastric ulcer. • symptomatic nonerosive gastroesophageal reflux disease (GERD). • erosive esophagitis due to GERD, diagnosed by biopsy. Ranitidine-induced thrombocytopenia. Arch Intern Med 1991;151:203. Back to cited text no. 10. 11. Humphries JE. Thrombocytopenia associated with famotidine ...pantoprazole to famotidine due to possible PPI-induced thrombocytopenia. Consequently, pantoprazole therapy was discontinued, oral famotidine 10 mg once daily was initiated, and 2 units of platelets were 2022 Phan et al. Cureus 14(2): e22326. DOI 10.7759/cureus.22326 2 of 6Kansas Journal of Medicine 2015 Famotidine-Induced Thrombocytopenia 26 . Probable Famotidine-Induced Thrombocytopenia . Ahmad Rahal, M.D.1, Mohamad El-Hawari, M.D.2 ...In contrast to immune-mediated thrombocytopenia, nonimmune drug-induced thrombocytopenia is described as a direct …The oral LD50 of famotidine in male and female rats and mice was greater than 3000 mg/kg and the minimum lethal acute oral dose in dogs exceeded 2000 mg/kg. Famotidine did not produce overt effects at high oral doses in mice, rats, cats and dogs, but induced significant anorexia and growth depression in rabbits starting with 200 mg/kg/day ...The incidence of thrombocytopenia in neurosurgical patients prescribed famotidine is unknown. Using hospital records of neurosurgery patients treated between July 2001 and July 2002, a retrospective cohort study was performed comparing platelet counts in patients treated with famotidine with a similar group of patients who were not prescribed ...UpToDate, electronic clinical resource tool for physicians and patients that provides information on Adult Primary Care and Internal Medicine, Allergy and Immunology, Cardiovascular Medicine, Emergency Medicine, Endocrinology and Diabetes, Family Medicine, Gastroenterology and Hepatology, Hematology, Infectious Diseases, Nephrology and Hypertension, Neurology, …Heparin‐induced thrombocytopenia (HIT) is a prothrombotic disorder with autoimmune‐like features [1]. The immune response targets the ‘self’ protein, platelet factor 4 (PF4), which forms autoreactive epitopes when bound to heparin or other polyanions, including platelet‐associated chondroitin sulfate [2]. IgG/PF4/polyanion complexes result, which activate platelets via their …Chronic therapy with famotidine has been associated with minor elevations in serum aminotransferase levels in 1% to 4% of patients, but similar rates were reported in placebo recipients. The ALT elevations are usually asymptomatic and transient, and may resolve without dose modification. Rare instances of clinically apparent liver injury have been reported in …We would like to show you a description here but the site won’t allow us.Thrombocytopenia is a rare adverse effect of famotidine therapy. 4-7. Few cases of famotidine-induced thrombocytopenia have been reported. Case reports have suggested two potential mechanisms of H2 antagonist-induced thrombocytopenia. The first is bone marrow suppression secondary to inhibition of DNA synthesis. The second mechanismFor famotidine, if the eGFR is less than 50 mL/minute/1.73m 2, prescribe the normal dose once every 36–48 hours, ... confusion, hallucinations, leucopenia, thrombocytopenia, and pancytopenia, arthralgia, and myalgia. Drug interactions. Possible drug interactions with histamine (H 2)-receptor antagonists (H 2 RAs) include:Ranitidine-induced thrombocytopenia. Arch Intern Med 1991;151:203. Back to cited text no. 10. 11. Humphries JE. Thrombocytopenia associated with famotidine ...Oct 1, 1998 · Famotidine binds more tightly to H 2 R (dissociation constant 17 nmol/L) than ranitidine (dissociation constant 200 nmol/L),16 but preincubation of platelets with 1.0 mmol/L famotidine had no significant effect on ranitidine-dependent binding of antibody to platelets at concentrations of ranitidine as low as 1.0 μmol/L . 2023 ASCO Annual Meeting. Springer Medicine. SearchHeparin‐induced thrombocytopenia (HIT) is a prothrombotic disorder with autoimmune‐like features [1]. The immune response targets the ‘self’ protein, platelet factor 4 (PF4), which forms autoreactive epitopes when bound to heparin or other polyanions, including platelet‐associated chondroitin sulfate [2]. IgG/PF4/polyanion complexes result, which activate platelets via their Fcγ ...Use gauze or a clean towel. If possible, elevate the body part above the level of your heart. If your nose bleeds, pinch the top of your nose until bleeding stops. Be careful with skin and mouth care. Use a soft washcloth when you bathe. Use a soft toothbrush to keep your gums from bleeding.Report signs of agranulocytosis and neutropenia (fever, sore throat, mucosal lesions, signs of infection, bruising), aplastic anemia (unusual fatigue, weakness), or thrombocytopenia (bruising, bleeding gums, nose bleeds).This study aimed to investigate the development of thrombocytopenia in patients with short-term use of PPI-infusion therapy. In this study, the records of the patients were evaluated retrospectively, for the period between January 2012 and January 2013. Thirty-five patients with upper gastrointestinal bleeding were enrolled.
The use of PEPCID 20 mg and 40 mg tablets is not recommended for use in pediatric patients weighing less than 40 kg because the lowest available strength (20 mg) exceeds the recommended dose for these patients. Use another famotidine formulation for pediatric patients weighing less than 40 kg. . Computer coding schools near me
Neutropenia and thrombocytopenia. Stop nilotinib and monitor blood cell counts; Resume within 2 weeks to original dose if ANC >1.5 x 10 9 /L and/or platelets >75 x 10 9 /L; ... famotidine. famotidine decreases levels of nilotinib by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely.Drug-induced thrombocytopenia (DITP), which also includes thrombocytopenia induced by beverages, foods, and herbal remedies, is an important clinical problem for hematologists. DITP typically appears suddenly, is often severe, and can cause major bleeding and death. 1 – 3 In many patients, the drug etiology is not initially recognized.Separate topics discuss management in different populations and the rare syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT): Outpatients – (See "COVID-19: Management of adults with acute illness in the outpatient setting".) Inpatients – (See "COVID-19: Management in hospitalized adults".)Patients receiving other drugs or with known bleeding in the upper part of the gastrointestinal tract, thrombocytopenia, or coagulopathy were excluded. Results: A total of 522 patients who received famotidine and 95 who received pantoprazole were included. Bleeding in the upper part of the gastrointestinal tract was more common in patients ...PURPOSE: Patients on mechanical ventilation (MV) are at increased risk of gastrointestinal bleeding (GIB). Proton pump inhibitors (PPIs), though more potent and longer acting inhibitors of gastric acid production, are generally more expensive than Histamine-2-Receptor Antagonists (an H2RA). Data comparing the two as prophylactic agents to prevent gastrointestinal bleeding in critically ill ...Thrombocytopenia is a medical condition characterized by a low platelet count in the blood. Normally, platelets are responsible for blood clotting, and a low platelet count can lead to bleeding, bruising, and other complications. Thrombocytopenia is said when platelet count falls below 150,000. Thrombocytopenia can be caused by diseases that ...Some side effects of famotidine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. ... Rare (0.01% to 0.1%): Thrombocytopenia, leukopenia ...famotidine formulation for pediatric patients weighing less than 40 kg. Table 1: Recommended Dosage and Duration of PEPCID Tablets in Adults and ... thrombocytopenia . Hypersensitivity: orbital edema, rash, conjunctival injection, bronchospasm . Musculoskeletal: musculoskeletal pain, arthralgia .The phase IV clinical study analyzes which people take Pepcid and have Thrombocytopenia. It is created by eHealthMe based on reports of 48,403 people who have side effects when taking Pepcid from the FDA, and is updated regularly. You can use the study as a second opinion to make health care decisions. Phase IV trials are used to detect adverse ...Introduction. Immune thrombocytopenia (ITP) is an immune-mediated disease characterized by transient or persistent decrease in the platelet count and increased risk of bleeding [].ITP in adults is a clinically distinct condition from that in children, with a lower likelihood of spontaneous remission, a higher incidence of underlying diseases and …Famotidine is a competitive inhibitor of histamine H 2-receptors. The primary clinically important pharmacologic activity of Famotidine is inhibition of gastric secretion. ... Hematologic: rare cases of agranulocytosis, pancytopenia, leukopenia, thrombocytopenia. Hypersensitivity: anaphylaxis, angioedema, orbital or facial edema, urticaria ...Seventy-two of 181 (39.8%) patients treated with famotidine developed thrombocytopenia compared with 23 of 126 (18.3%) untreated patients (P < 0.001). Patients who developed thrombocytopenia were also more likely to have a longer length of stay and higher Injury Severity Scores..